Illuminating Biochemical Activity Architecture of the Cell

Research Seminar
Title: Illuminating Biochemical Activity Architecture of the Cell
Speaker: Jin Zhang，Ph.D.
Professor,
Department of Pharmacology,
Department of Bioengineering and Department of Chemistry and Biochemistry,
The university of California, San Diego
Adjunct Professor,
Department of Pharmacology & Molecular Sciences,
The Johns Hopkins University School of Medicine
Time: 13:00-14:30, Mar.  31, 2017
Location: Youcai Deng Hall，School of Life Sciences（生科院邓祐才报告厅）
Abstract:
The complexity and specificity of many forms of signal transduction are widely suspected to require spatiotemporal regulation of signaling molecules, such as protein kinases, phosphatases and second messengers. These signaling activities are often compartmentalized in nanoscale domains that define the biochemical architecture of the cell. Despite advances in molecular sensors and optical imaging, direct interrogation of any minute activity domains at the molecular length scale remains a challenge. In this talk, I will focus on cAMP and Ca2+ regulated signaling activities and present studies where we combined genetically encoded fluorescent biosensors, superresolution imaging, targeted biochemical perturbations and mathematic modeling to probe the biochemical activity architecture of the cell.
Welcome！