Prof. Yulong Li published a paper in Science.
Neuropeptides and their receptors are ancient, potent, and ubiquitous signaling molecules that can exert persistent control of physiology and behavior. However, despite the high functional importance of neuropeptides, when, where, and how they exert their effects in complex brain systems is poorly understood. Wang et al. developed and characterized a series of genetically encoded sensors for detecting neuropeptides (see the Perspective by Romanov and Harkany). These sensors had a highly sensitive, specific, and robust response to their respective ligands in both cell lines and primary neurons without affecting endogenous signaling pathways. These new tools provide the opportunity to address key questions regarding neuropeptides, their function, and their role in both health and disease.
Original link: https://www.science.org/doi/10.1126/science.abq8173.
