教育经历:

2000-2006年，博士，神经生物学系，杜克大学
1996-2000年，学士，我院，太阳集团见好就收9728

工作经历:

2020-今，教授，我院，太阳集团见好就收9728
2012-今，研究员，我院，生命科学联合中心，麦戈文脑研究所，太阳集团见好就收9728
2019-2020年，副教授，我院，太阳集团见好就收9728
2012-2019年，助理教授，我院，太阳集团见好就收9728
2006-2012年，博士后，分子和细胞生理学系，斯坦福大学

荣誉奖励:

2022年度拜耳中国科研合作奖——拜耳研究员奖，2023
首届“峰基金”获得者，2021
教育部基础学科拔尖学生培养计划“优秀导师奖”，2020
北脑学者，2020
科学探索奖生命科学奖，2019
国家杰出青年科学基金，2019
第十二届谈家桢生命科学创新奖，2019
张香桐神经科学青年科学家奖，2019
中国十大医学科技新闻，2018
中国生命科学十大进展，中国科协生命科学学会联合体，2018
中源协和生命医学奖创新突破奖，2018
勃林格殷格翰研究员奖，2018
绿叶生物医药杰出青年学者奖，2015

学术任职:

2023-今，Neuron，顾问
2022-2024，美国神经科学学会，委员会成员
2022-今，National Science Review，编委
2019-今，Journal of Neurochemistry，编委

执教课程:

高级神经生物学
生命科学前沿文献阅读讨论
综合科学实验课程
遗传学讨论课
神经生物学进展
现代生物学实验技术原理及其应用
高级生物物理学
心理/神经/脑科学基础

      人的大脑由数十亿的神经元组成，后者又通过数万亿的突触组成复杂的神经网络。不同种类的神经元经过或远或近的投射，通过突触与其他神经元进行信息交流，实现感知觉、决策和运动等高级神经功能。
研究大脑的最大挑战在于脑的高度复杂性。我们实验室集中在神经元通讯的基本结构突触上，从两个层面上开展研究：一是开发前沿的工具，即开发新型成像探针，用于在时间和空间尺度上解析神经系统的复杂功能；二是借助先进的工具探究突触传递的调节机制，特别是在生理及病理条件下对神经递质释放的调节。
具体而言，对于工具开发，我们集中于：
　　1，结合光遗传学和荧光成像，无损伤性的研究神经元之间的电突触连接。电突触的异常可导致耳聋、癫痫、脑部肿瘤和心脏功能异常等疾病。
　　2，开发可遗传编码的检测神经递质/调质的荧光探针。神经递质/调质是神经元化学突触传递的关键介导分子，与感知、学习和记忆以及情绪密切相关。
利用上述荧光探针，我们的功能性和生理性的研究集中于：
　　1，结合双光子成像和可遗传编码的荧光探针，使用果蝇和小鼠作为模式生物，研究嗅觉传导或睡眠过程中脑的工作机制。
　　2，寻找上述新型化学递质/调质小分子的对应受体，即寻找“孤儿”受体的配体。
　　3，结合生物信息学、分析化学、生物化学、生理学和成像学方法，系统地探索和鉴定潜在的新型小分子神经递质。

Main Research Articles

· Wu, Z.#, Cui, Y.#, Wang, H.#, Wu, H., Wan, Y., Li, B., Wang, L., Pan, S., Peng, W., Dong, A., Yuan, Z., Jing, M., Xu, M., Luo, M.*, & Li, Y.* (2023). Neuronal activity-induced, equilibrative nucleoside transporter-dependent, somatodendritic adenosine release revealed by a GRAB sensor. Proceedings of the National Academy of Sciences, 120(14), e2212387120.
· Dong, H.#, Li, M.#, Yan, Y., Qian, T., Lin, Y., Ma, X., Vischer, H. F., Liu, C., Li, G., Wang, H., Leurs, R., & Li, Y.* (2023). Genetically encoded sensors for measuring histamine release both in vitro and in vivo. Neuron.
· Zeng, J.#*, Li, X.#, Zhang, R., Lv, M., Wang, Y., Tan, K., Xia, X., Wan, J., Jing, M., Zhang, X., Li, Y., Yang, Y., Wang, L., Chu, J., Li, Y., & Li, Y.*. (2023). Local 5-HT signaling bi-directionally regulates the coincidence time window for associative learning. Neuron.
· Qian, T.#, Wang, H.#, Wang, P.#, Geng, L., Mei, L., Osakada, T., Wang, L., Tang, Y., Kania, A., Grinevich, V., Stoop, R., Lin, D., Luo, M., & Li, Y.* (2023). A genetically encoded sensor measures temporal oxytocin release from different neuronal compartments. Nature Biotechnology.
· Wu, Z.*, He, K., Chen, Y., Li, H., Pan, S., Li, B., Liu, T., Wang, H., Du, J., Jing, M., & Li, Y.* (2021). A sensitive GRAB sensor for detecting extracellular ATP in vitro and in vivo Neuron, 110(5), 770-782.e775.
· Dong, A., He, K., Dudok, B., Farrell, J. S., Guan, W., Liput, D. J., Puhl, H. L., Cai, R., Wang, H., Duan, J., Albarran, E., Ding, J., Lovinger, D. M., Li, B., Soltesz, I., & Li, Y.*. (2021). A fluorescent sensor for spatiotemporally resolved imaging of endocannabinoid dynamics in vivo. Nature Biotechnology.
· Wan, J., Peng, W., Li, X., Qian, T., Song, K., Zeng, J., Deng, F., Hao, S., Feng,J., Zhang, P., Zhang, Y., Zou, J., Pan, S., Shin, M., Venton, B. J., Zhu, J. J., Jing, M., Xu, M., Li, Y.*.(2021). A genetically encoded sensor for measuring serotonin dynamics. Nature Neuroscience, https://doi.org/10.1038/s41593-021-00823-7.
· Qian, C., Wu, Z., Sun, R., Yu, H., Zeng, J., Rao, Y., & Li, Y. * (2021). Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose. eLife, 10, e65417.
· Sun, F.#, Zhou, J.#, Dai, B.#, Qian, T., Zeng, J., Li, X., Zhuo, Y., Zhang, Y., Wang, Y., Qian, C., Tan, K., Feng, J., Dong, H., Lin, D.*, Cui, G.*, & Li, Y.*.(2020). Next-generation GRAB sensors for monitoring dopaminergic activity in vivo. Nature Methods, https://doi.org/10.1038/s41592-020-00981-9.
· Jing, M.*, Li, Y., Zeng, J., Huang, P., Skirzewski, M., Kljakic, O., Peng, W., Qian, T., Tan, K., Wu, R., Zhang, S., Pan, S., Xu, M., Li, H., Saksida, L. M., Prado, V. F., Bussey, T., Prado, M. A. M., Chen, L., Cheng, H., Li, Y.*.(2020). An optimized acetylcholine sensor for monitoring in vivo cholinergic activity. Nature Methods, https://doi.org/10.1038/s41592-020-0953-2.
· Yu, H., Zhao, T., Liu, S., Wu, Q., Johnson, O., Wu, Z., Zhuang, Z., Shi, Y., He, R., Yang, Y., Sun, J., Wang, X., Xu, H., Zeng, Z., Lei, X., Luo, W.* & Li, Y.*. (2019). MRGPRX4 is a bile acid receptor for human cholestatic itch. eLife, 8, e48431.
· Feng, J., Zhang, C., Lischinsky, J. E., Jing, M., Zhou, J., Wang, H., Zhang, Y., Dong, A., Wu, Z., Wu, H., Chen, W., Zhang, P., Zou, J., Hires, S. A., Zhu, J. J., Cui, G., Lin, D., Du, J. & Li, Y.* (2019). A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine. Neuron, 102(4), 745-761.
· Wu, Z.#, Feng, J.#, Jing, M., & Li, Y.* (2019). G protein-assisted optimization of GPCR-activation based (GRAB) sensors. Neural Imaging and Sensing 2019, vol. 10865, p. 108650N. International Society for Optics and Photonics.
· Wu, L., Dong, A., Dong, L., Wang, S. Q., & Li, Y*. (2019). PARIS, an optogenetic method for functionally mapping gap junctions. eLife, 8, e43366.
· Sun, F.#, Zeng, J.#, Jing, M.#, Zhou, J., Feng, J., Owen, S., Luo, Y., Li, F., Wang, H., Yamaguchi, T., Yong, Z., Gao, Y., Peng, W., Wang, L., Zhang, S., Du, J., Lin, D., Xu, M., Kreitzer, A. C., Cui, G. & Li, Y.* (2018). A genetically-encoded fluorescent sensor enables rapid and specific detection of dopamine in flies, fish, and mice. Cell, 174(2), 481-496.
· Jing, M.#, Zhang, P.#, Wang, G., Feng, J., Mesik, L., Zeng, J., Jiang, H., Wang, S., Looby, J. C., Guagliardo, N. A., Langma, L. W., Lu, J., Zuo, Y., Talmage, D. A., Role, L. W., Barrett, P. Q., Zhang, L. I., Luo, M., Song, Y., Zhu, JJ* & Li, Y*. (2018). A genetically-encoded fluorescent acetylcholine indicator for in vitro and in vivo studies. Nature Biotechnology, 36(8), 726-737.
· Li, Y.*, & Tsien, R. W.* (2012). pHTomato, a red, genetically encoded indicator that enables multiplex interrogation of synaptic activity. Nature neuroscience, 15(7), 1047-1053.
· Li, Y., Augustine, G. J., & Weninger, K.* (2007). Kinetics of complexin binding to the SNARE complex: correcting single molecule FRET measurements for hidden events. Biophysical journal, 93(6), 2178-2187.

Collaborative Publications

· Peng, W.*, Liu, X., Ma, G., Wu, Z., Wang, Z., Fei, X., Qin, M., Wang, L., Li, Y., Zhang, S.*, & Xu, M.* (2023). Adenosine-independent regulation of the sleep–wake cycle by astrocyte activity. Cell Discovery, 9(1), 16.
· Asher, M. J., McMullan, H. M., Dong, A., Li, Y., & Thayer, S. A.* (2023) A Complete Endocannabinoid Signaling System Modulates Synaptic Transmission between Human Induced Pluripotent Stem Cell-Derived Neurons. Mol Pharmacol , 103(2), 100-112.
· Natsubori, A.*, Hirai, S., Kwon, S., Ono, D., Deng, F., Wan, J., Miyazawa, M., Kojima, T., Okado, H., Karashima, A., Li, Y., Tanaka, K. F., & Honda, M. (2023). Serotonergic neurons control cortical neuronal intracellular energy dynamics by modulating astrocyte-neuron lactate shuttle. iScience, 105830.
· Ono, D.*, Wang, H., Hung, C. J., Wang, H.-t., Kon, N., Yamanaka, A.,Li, Y., & Sugiyama, T. Network-driven intracellular cAMP coordinates circadian rhythm in the suprachiasmatic nucleus. Science Advances, 9(1), eabq7032.
· Reggiani, J. D. S., Jiang, Q., Barbini, M., Lutas, A., Liang, L., Fernando, J., Deng, F., Wan, J., Li, Y., Chen, C.*, & Andermann, M. L.* (2022). Brainstem serotonin neurons selectively gate retinal information flow to thalamus. Neuron.
· Pittolo, S., Yokoyama, S., Willoughby, D. D., Taylor, C. R., Reitman, M. E., Tse, V., Wu, Z., Etchenique, R., Li, Y., & Poskanzer, K. E.* (2022). Dopamine activates astrocytes in prefrontal cortex via α1-adrenergic receptors. Cell Reports, 40(13), 111426.
· Li, X.#, Li, Y.#, Zhou, Y., Wu, J., Zhao, Z., Fan, J., Deng, F., Wu, Z., Xiao, G., He, J., Zhang, Y., Zhang, G., Hu, X., Chen, X., Zhang, Y., Qiao, H., Xie, H., Li, Y., Wang, H.*, Fang, L.*, & Dai, Q.* (2022). Real-time denoising enables high-sensitivity fluorescence time-lapse imaging beyond the shot-noise limit. Nature Biotechnology.
· Lohani, S.#, Moberly, A. H.#, Benisty, H., Landa, B., Jing, M., Li, Y., Higley, M. J.*, & Cardin, J. A.* (2022). Spatiotemporally heterogeneous coordination of cholinergic and neocortical activity. Nature Neuroscience, 25(12), 1706-1713.
· Wang, L.#, Wu, C.#, Peng, W., Zhou, Z., Zeng, J., Li, X., Yang, Y., Yu, S., Zou, Y., Huang, M., Liu, C., Chen, Y., Li, Y., Ti, P., Liu, W., Gao, Y., Zheng, W., Zhong, H., Gao, S., Lu, Z., Ren, P.-G., Ng, H. L., He, J., Chen, S., Xu, M., Li, Y., & Chu, J.* (2022). A high-performance genetically encoded fluorescent indicator for in vivo cAMP imaging. Nature Communications, 13(1), 5363.
· Sheu, S.-H.*, Upadhyayula, S., Dupuy, V., Pang, S., Deng, F., Wan, J., Walpita, D., Pasolli, H. A., Houser, J., Sanchez-Martinez, S., Brauchi, S. E., Banala, S., Freeman, M., Xu, C. S., Kirchhausen, T., Hess, H. F., Lavis, L., Li, Y., Chaumont-Dubel, S., & Clapham, D. E.* (2022). A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility. Cell, 185(18), 3390-3407.e3318.
· Dai, B.*, Sun, F., Tong, X., Ding, Y., Kuang, A., Osakada, T., Li, Y., & Lin, D.* (2022). Responses and functions of dopamine in nucleus accumbens core during social behaviors. Cell Reports, 40(8), 111246.
· Lin, R.*#, Zhou, Y.#, Yan, T.#, Wang, R.#, Li, H., Wu, Z., Zhang, X., Zhou, X., Zhao, F., Zhang, L., Li, Y., & Luo, M.* (2022). Directed evolution of adeno-associated virus for efficient gene delivery to microglia. Nat Methods, 19(8), 976-985.
· Li, H.#, Namburi, P.#, Olson, J. M.#, Borio, M., Lemieux, M. E., Beyeler, A., Calhoon, G. G., Hitora-Imamura, N., Coley, A. A., Libster, A., Bal, A., Jin, X., Wang, H., Jia, C., Choudhury, S. R., Shi, X., Felix-Ortiz, A. C., de la Fuente, V., Barth, V. P., King, H. O., Izadmehr, E. M., Revanna, J. S., Batra, K., Fischer, K. B., Keyes, L. R., Padilla-Coreano, N., Siciliano, C. A., McCullough, K. M., Wichmann, R., Ressler, K. J., Fiete, I. R., Zhang, F., Li, Y., & Tye, K. M.* (2022). Neurotensin orchestrates valence assignment in the amygdala. Nature.
· Mo, J.#, Chen, J.#, Shi, Y., Sun, J., Wu, Y., Liu, T., Zhang, J., Zheng, Y., Li, Y., & Chen, Z.* (2022). Third-Generation Covalent TMP-Tag for Fast Labeling and Multiplexed Imaging of Cellular Proteins Angewandte Chemie International Edition, e202207905.
· Yu, X.#*, Zhao, G.#, Wang, D., Wang, S., Li, R., Li, A., Wang, H., Nollet, M., Chun, Y. Y., Zhao, T., Yustos, R., Li, H., Zhao, J., Li, J., Cai, M., Vyssotski, A. L., ,Li, Y., Dong, H.*, Franks, N. P.*, & Wisden, W.* (2022). A specific circuit in the midbrain detects stress and induces restorative sleep. Science, 377(6601), 63-72.
· Kjaerby, C.*, Andersen, M., Hauglund, N., Untiet, V., Dall, C., Sigurdsson, B., Ding, F., Feng, J., Li, Y., Weikop, P., Hirase, H., & Nedergaard, M.* (2022). Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine. Nature Neuroscience.
· Han, J., Yoon, J., Shin, J., Nam, E., Qian, T.,Li, Y., Park, K.*, Lee, S.-H.*, & Lim, M. H.* (2022). Conformational and functional changes of the native neuropeptide somatostatin occur in the presence of copper and amyloid-β. Nature Chemistry.
· Klein Herenbrink, C.#, Støier, J. F.#, Reith, W. D., Dagra, A., Gregorek, M. A. C., Cola, R. B., Patriarchi, T., Li, Y., Tian, L., Gether, U., & Herborg, F.* (2022). Multimodal detection of dopamine by sniffer cells expressing genetically encoded fluorescent sensors. Communications Biology, 5(1), 578.
· Breton-Provencher, V.#*, Drummond, G. T.#, Feng, J., Li, Y., & Sur, M.* (2022). Spatiotemporal dynamics of noradrenaline during learned behaviour. Nature.
· Koh, W., Park, M., Chun, Y. E., Lee, J., Shim, H. S., Park, M. G., Kim, S., Sa, M., Joo, J., Kang, H., Oh, S.-J., Woo, J., Chun, H., Lee, S. E., Hong, J., Feng, J., Li, Y., Ryu, H., Cho, J., & Lee, C. J. (2021). Astrocytes Render Memory Flexible by Releasing D-Serine and Regulating NMDA Receptor Tone in the Hippocampus. Biological Psychiatry, 91(8), 740-752.
· Stahl, A., Noyes, N. C., Boto, T., Botero, V., Broyles, C. N., Jing, M., Zeng, J., King, L. B., Li, Y., Davis, R. L., & Tomchik, S. M.* (2022). Associative learning drives longitudinally graded presynaptic plasticity of neurotransmitter release along axonal compartments. eLife, 11.
· Liu, C.*, Cai, X., Ritzau-Jost, A., Kramer Paul, F., Li, Y.., Khaliq Zayd, M., Hallermann, S., & Kaeser Pascal, S.* (2022). An action potential initiation mechanism in distal axons for the control of dopamine release. Science, 375(6587), 1378-1385.
· Hasegawa, E., Miyasaka, A., Sakurai, K., Cherasse, Y., Li, Y.., & Sakurai, T.* (2022) Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice. Science, 375(6584), 994-1000.
· Liput, D. J., Puhl, H. L., Dong, A., He, K., Li, Y., & Lovinger, D. M. (2022). 2-Arachidonoylglycerol mobilization following brief synaptic stimulation in the dorsal lateral striatum requires glutamatergic and cholinergic neurotransmission. Neuropharmacology, 205, 108916.
· Deng, H.*, Xiao, X., Yang, T., Ritola, K., Hantman, A., Li, Y., Huang, Z. J., & Li, B.* (2021). A genetically defined insula-brainstem circuit selectively controls motivational vigor. Cell, 184(26), 6344-6360.e6318.
· Hamilos, A. E., Spedicato, G., Hong, Y., Sun, F., Li, Y., & Assad, J. (2021). Slowly evolving dopaminergic activity modulates the moment-to-moment probability of reward-related self-timed movements. eLife,, 10, e62583.
· Lu, C.-L.#, Ren, J.#, Mo, J.-W., Fan, J., Guo, F., Chen, L.-Y., Wen, Y.-L., Li, S.-J., Fang, Y.-Y., Wu, Z.-F., Li, Y., Gao, T.-M., & Cao, X.*(2021) Glucocorticoid receptor-dependent astrocytes mediate stress vulnerability. Biological Psychiatry, 12(1), 6403.
· Gallo, E. F.*, Greenwald, J., Yeisley, J., Teboul, E., Martyniuk, K. M., Villarin, Jing, M., Li, Y., Javitch, J. A., Balsam, P. D., & Kellendonk, C*. (2022). Dopamine D2 receptors modulate the cholinergic pause and inhibitory learning. Mol Psychiatry, 27(3), 1502-1514.
· Robert, B., Kimchi, E. Y., Watanabe, Y., Chakoma, T., Jing, M., Li, Y., & Polley, D. B. (2021). A functional topography within the cholinergic basal forebrain for encoding sensory cues and behavioral reinforcement outcomes. eLife, 10, e69514.
· Guo, W.#, Fan, S.#, Xiao, D., Dong, H., Xu, G., Wan, Z., Ma, Y., Wang, Z., Xue, T., Zhou, Y., Li, Y., & Xiong, W.* (2021). A Brainstem reticulotegmental neural ensemble drives acoustic startle reflexes. Nature Communications, 12(1), 6403.
· Foo, C., Lozada, A., Aljadeff, J., Li, Y., Wang, J. W., Slesinger, P. A.*, & Kleinfeld, D.* (2021). Reinforcement learning links spontaneous cortical dopamine impulses to reward. Current Biology, 31(18), 4111-4119.e4114.
· Li, Y., Simmler Linda, D., Van Zessen, R., Flakowski, J., Wan, J.-X., Deng, F., Li, Y.-L., Nautiyal Katherine, M., Pascoli, V., & Lüscher, C.* (2021) Synaptic mechanism underlying serotonin modulation of transition to cocaine addiction. Science, 73(6560), 1252-1256.
· Al-Hasani, R.#*, Gowrishankar, R.#, Schmitz, G. P.#, Pedersen, C. E., Marcus, D. J., Shirley, S. E., Hobbs, T. E., Elerding, A. J., Renaud, S. J., Jing, M., Li, Y., Alvarez, V. A., Lemos, J. C., & Bruchas, M. R*. (2021). Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement. Nature Neuroscience, 24, 1414–1428.
· Farrell, J. S.*, Colangeli, R., Dong, A., George, A. G., Addo-Osafo, K., Kingsley, P. J., Morena, M., Wolff, M. D., Dudok, B., He, K., Patrick, T. A., Sharkey, K. A., Patel, S., Marnett, L. J., Hill, M. N., Li, Y., Teskey, G. C., & Soltesz, I. (2021). In vivo endocannabinoid dynamics at the timescale of physiological and pathological neural activity. Neuron,, 109(15), 2398-2403.e2394.
· Huang, M.#, Li, D.#*, Pei, Q.#, Xie, Z., Gu, H., Zhang, X., Chen, Z., Liu, A., Wang, Y., Sun, F., Li, Y., Zhang, J., He, M., Xie, Y., Zhang, F., Qi, X., Shang, C.*, & Cao, P.*(2021). The tectonigral pathway regulates appetitive locomotion in predatory hunting in mice Nature Communications, 12, 4409.
· Wang, Q.#, Kong, Y.#, Wu, D., Liu, J., Jie, W., You, Q., Huang, L., Hu, J., Chu, H., Gao, F., Hu, N., Luo, Z., Li, X., Li, S., Wu, Z., Li, Y., Yang, J.*, & Gao, T.* (2021). Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice. Nature Communications, 12(1), 3321.
· Pribiag, H., Shin, S., Wang, E. H., Sun, F., Datta, P., Okamoto, A., Guss, H., Jain, A., Wang, X. Y., De Freitas, B., Honma, P., Pate, S., Lilascharoen, V., Li, Y., & Lim, B. K.* (2021). Ventral pallidum DRD3 potentiates a pallido-habenular circuit driving accumbal dopamine release and cocaine seeking. Neuron, https://doi.org/10.1016/j.neuron.2021.05.002
· Zhang, Y.#, Cao, L.#, Varga, V., Jing, M., Karadas, M., Li, Y., & Buzsáki, G.* (2021). Cholinergic suppression of hippocampal sharp-wave ripples impairs working memory. Proceedings of the National Academy of Sciences, 118(15), e2016432118. https://doi.org/10.1073/pnas.2016432118.
· Bai, J., Guo, F., Li, M., Li, Y.*, & Lei, X.* (2021). Click-based amplification: designed to facilitate various target labelling with ultralow background. RSC Chemical Biology, https://doi.org/10.1039/D1CB00002K.
· Zeng, Y.#, Luo, H.#, Gao, Z., Zhu, X., Shen, Y., Li, Y., Hu, J.*, & Yang, J.* (2021). Reduction of prefrontal purinergic signaling is necessary for the analgesic effect of morphine. iScience，24(3), 102213. https://doi.org/https://doi.org/10.1016/j.isci.2021.102213.
· Sethuramanujam, S.#, Matsumoto, A.#, deRosenroll, G., Murphy-Baum, B., McIntosh, J. M., Jing, M., Li, Y., Berson, D., Yonehara, K.*, & Awatramani, G. B.* (2021). Rapid multi-directed cholinergic transmission in the central nervous system. Nature Communications, https://doi.org/10.1038/s41467-021-21680-9.
· Wang, J.#, Li, J.#, Yang, Q.#, Xie, Y.-K., Wen, Y.-L., Xu, Z.-Z., Li, Y., Xu, T., Wu, Z.-Y., Duan, S., & Xu, H.* (2021). Basal forebrain mediates prosocial behavior via disinhibition of midbrain dopamine neurons. Proceedings of the National Academy of Sciences，118(7), e2019295118. https://doi.org/10.1073/pnas.2019295118。
· Song, Y., Xu, C., Liu, J., Li, Y., Wang, H., Shan, D., Wainer Irving, W., Hu, X., Zhang, Y.*, Woo Anthony, Y.-H.*, & Xiao, R.-P. Heterodimerization with 5-HT2BR Is Indispensable for β2AR-mediated Cardioprotection. Circulation Research, https://doi.org/10.1161/CIRCRESAHA.120.317011。
· Zhu, R.#, Zhang, G.#, Jing, M., Han, Y., Li, J., Zhao, J., Li, Y., & Chen, P. R.* (2021, 2021/01/25). Genetically encoded formaldehyde sensors inspired by a protein intra-helical crosslinking reaction. Nature Communications,，12(1), 581. https://doi.org/10.1038/s41467-020-20754-4。
· Mayer, F. P., Iwamoto, H., Hahn, M. K., Grumbar, G. J., Stewart, A., Li, Y., & Blakely, R. D.* (2021). There`s no place like home? Return to the home cage triggers dopamine release in the mouse nucleus accumbens. Neurochemistry International, 142, 104894. https://doi.org/https://doi.org/10.1016/j.neuint.2020.104894
· Bari*, A., Xu, S., Pignatelli, M., Takeuchi, D., Feng, J., Li, Y., & Tonegawa, S.* (2020). Differential attentional control mechanisms by two distinct noradrenergic coeruleo-frontal cortical pathways. Proceedings of the National Academy of Sciences, https://doi.org/10.1073/pnas.2015635117。
· Kim, H. R.*, Malik, A. N., Mikhael, J. G., Bech, P., Tsutsui-Kimura, I., Sun, F., Zhang, Y., Li, Y., Watabe-Uchida, M., Gershman, S. J., & Uchida, N.* (2020). A Unified Framework for Dopamine Signals across Timescales. Cell, https://doi.org/https://doi.org/10.1016/j.cell.2020.11.013。
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· Mazzone, C.M., Liang-Guallpa, J.,Li, C., Wolcott, N. S., Boone, M. H., Southern, M., Kobzar, N. P., Salgado, I. A., Reddy, D. M., Sun, F., Zhang, Y., Li, Y., Cui, G. * & Krashes, M. J.* (2020). High-fat food biases hypothalamic and mesolimbic expression of consummatory drives. Nature Neuroscience, https://doi.org/10.1038/s41593-020-0684-9.
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· Lin, R., Liang, J., Wang, R., Yan, T., Zhou, Y., Liu, Y., Feng, Q., Sun, F.,, Li, Y., Li, A., Gong, H., & Luo, M.* (2020). The Raphe Dopamine System Controls the Expression of Incentive Memory. Neuron, 1420-19.
· Zhang, X., Noyes, N. C. , Zeng, J., Li, Y. & Davis, R. L.* (2019). Aversive Training Induces Both Pre- and Postsynaptic Suppression in Drosophila. The Journal of Neuroscience, 1420-19.
· Handler, A., Graham, T. G. M., Cohn, R., Morantte, I., Siliciano, A. F., Zeng J., Li, Y. & Ruta, V.* (2019). Distinct dopamine receptor pathways underlie the temporal sensitivity of associative learning. Cell, 178(1), 60-75.
· Liang, X., Ho, M. C., Zhang, Y., Li, Y., Wu, M. N., Holy, T. E., & Taghert, P. H.* (2019). Morning and Evening Circadian Pacemakers Independently Drive Premotor Centers via a Specific Dopamine Relay. Neuron, 102(4), 843-857.
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· Tanaka, M., Sun, F., Li, Y., & Mooney, R.* (2018). A mesocortical dopamine circuit enables the cultural transmission of vocal behaviour. Nature, 563(7729), 117-120.
· Chen, B.#, Huang, X.#, Gou, D., Zeng, J., Chen , G., Pang, M., Hu, Y., Zhao, Z., Wu, H., Cheng, H., Zhang, Z., Xu, C., & Li, Y., Chen, L.*, Wang, A.* (2018). Rapid volumetric imaging with Bessel-Beam three-photon microscopy. Biomedical optics express, 9(4), 1992-2000.
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Reviews, Book Reviews and Highlights

· Dong, C.#, Zheng, Y.#, Long-Iyer, K., Wright, E. C., Li, Y.*, & Tian, L.* (2022). Fluorescence imaging of neural activity, neurochemical dynamics, and drug-specific receptor conformation with genetically encoded sensors. Annual Review of Neuroscience.
· Wu, Z., Lin, D., & Li, Y.* (2022). Pushing the frontiers: tools for monitoring neurotransmitters and neuromodulators. Nature Reviews Neuroscience.
· Zhuo, Y., Li, Y.* (2022). New imaging methods for monitoring dopaminergic neurotransmission. Science China Life Sciences, 65.
· Yulong Li. (2021). Neuron, 109(21), 3346-3348.
· Yu, H., Wangensteen, K., Deng, T., Li, Y., & Luo, W.* (2021). MRGPRX4 in Cholestatic Pruritus. Semin Liver Dis41(03), 358-367.
· Wan, J. & Li, Y.* (2020). Recent Advances in Detection Methods for Neurotransmitters. Chinese Journal of Analytical Chemistry, 48(3), 307-315. (In Chinese)
· Wu, Z.* & Li, Y.* (2020). New frontiers in probing the dynamics of purinergic transmitters in vivo. Neuroscience Research, https://doi.org/10.1016/j.neures.2020.01.008.
· Zeng, J., Sun, F., Wan, J., Feng, J. & Li, Y.* (2019). New optical methods for detecting monoamine neuromodulators. Current Opinion in Biomedical Engineering, https://doi.org/10.1016/j.cobme.2019.09.010.
· Jing, M., Zhang, Y., Wang, H. & Li, Y.* (2019). GPCR‐based sensors for imaging neurochemicals with high sensitivity and specificity. Journal of Neurochemistry, https://doi.org/10.1111/jnc.14855.
· Dong, A.*, Liu, S., & Li, Y.* (2018). Gap Junctions in the Nervous System: Probing Functional Connections Using New Imaging Approaches. Frontiers in Cellular Neuroscience, 12, 320.
· Wang, H., Jing, M., & Li, Y.* (2018). Lighting up the brain: genetically encoded fluorescent sensors for imaging neurotransmitters and neuromodulators. Current Opinion in Neurobiology, 50, 171-178.
· Wang, A.#, Feng, J.#, Li, Y.*, & Zou, P.* (2018). Beyond Fluorescent Proteins: Hybrid and Bioluminescent Indicators for Imaging Neural Activities. ACS chemical neuroscience, 9(4), 639-650.
· Qian, C., & Li, Y.* (2015). Spine maturation and pruning during development: Cadherin/Catenin complexes come to help. Science China. Life sciences,58(9), 929.
· Li, Y.*, & Rao, Y.* (2015). Pied Piper of Neuroscience. Cell, 163(2), 267-268.